PELP1/MNAR suppression inhibits proliferation and metastasis of endometrial carcinoma cells
نویسندگان
چکیده
منابع مشابه
PELP1/MNAR suppression inhibits proliferation and metastasis of endometrial carcinoma cells.
Proline-, glutamic acid- and leucine-rich protein-1/modulator of non-genomic activity of estrogen receptor (ER) (PELP1/MNAR) is a novel nuclear receptor (NR) co-activator that plays an essential role in the actions of ER. Emerging findings suggest that PELP1/MNAR is a novel proto-oncogene, whose expression is deregulated in several hormone-respons...
متن کاملDownregulation of Kinesin Spindle Protein Inhibits Proliferation, Induces Apoptosis and Increases Chemosensitivity in Hepatocellular Carcinoma Cells
Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...
متن کاملDepletion of CCL27 inhibits cell proliferation, metastasis and adhesion in ectopic endometrial stromal cells
Endometriosis represents a multifaceted disease with controversial pathogenesis. Effective medical therapy for endometriosis is still urgently needed. In this study, we attempted to reveal the association between CCL27 and endometriosis to investigate new approach in the endometriosis etiology and treatment. We examined the expression of CCL27 in endometriotic tissue and serum samples. Then we ...
متن کاملMicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1
MicroRNAs (miRNAs or miRs) play a pivotal role in esophageal carcinogenesis either as oncogenes or as tumor suppressor genes. In the present study, we found that the expression level of miR-218 was significantly reduced in esophageal squamous cell carcinoma (ESCC) tissues and ESCC cell lines. Moreover, its expression was found to correlate with the clinicopathological stage of ESCC; miR-218 exp...
متن کاملAndrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells
To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase activity were assessed. Moreover, western blotting and real-time PCR were used to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncology Reports
سال: 2012
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2012.2038